• destek@morlab.com.tr
  • Antalya Teknokent Uluğbey Ar Ge 2 Konyaaltı/ANTALYA
İletişim

Elastases are enzymes released from neutrophils and dermal fibroblasts , and are thought to be produced through a signal cascade that is induced by skin inflammation resulting from UV damage. Neutrophils are typical inflammatory cells that secrete neutrophil elastase (NE) in the acute inflammation phase. NE is a well-studied elastase that cleaves a variety of proteins. A relationship between UV exposure and neutrophil infiltration in skin has been suggested, and it has been reported that neutrophil infiltration inhumanskinisobservedafter a single erythemaldose of irradiation by solar simulated radiation UV. It is known that interstitial collagenases MMP-1 mainly act as damage factors to type I collagen in the dermis, and their activity is elevated following UV irradiation NE indirectly plays a role in skin photoaging through MMP activation (1). Natural compounds are a potential source of HNE inhibitors (2).

·        Inhibits the production of MMP-which is a major protein involved in collagen breakdown

 

·        Increases skin density (as a result of increased collagen synthesis)

·        Protects cells against the effects of UV radiation exposure

 

·        Inhibiiıon of Neutrophil Elastase

 

 

Pratical Hints

 

Product Name

 

   ANTI-NSE COMPLEX
INCI Name

 

 Propanediol

Arnica montana Flower Extract

Hordeum vulgare Seed Extract
Dosage

 

  

Recommendations: 2-4%

Can be used in 1%-10% in various formulation type
Precautions

 

  

Use freely in any step to make any formulations
Storage

 

  

Storage period with original packing at general storing condition (at room temperature, normal dry condition)

Store in cool place. Keep container tightly closed in a dry and well-ventilated place

 
Specification

 

  

Apparance                          Between light yellow to yellowfish orange

Odor                                    Characteristic

Solubility                              Soluble in aqueous solutions

pH                                       3.0-5.5

Specific Gravity                  1.000-1.150 at 20 °C

Microbial Analysis               Less than 100 CFU per gram

 

Recommended Applications & Use Levels

Applications: For use in skin care products, especially those for ageing, anti-wrinkle.

Recommended use levels:  2-4%

 

References:

1- Takeuchi H., Gomi T., Shishido M., Watanabe H., Suenobu N.,2010. Neutrophil elastase contributes to extracellular matrix damage induced by chronic low-dose UV irradiation in a hairless mouse photoaging model. Journal of Dermatological Science, 60.

2- Feng L, Liu X, Zhu W, Guo F, YingchunWu, et al. (2013) Inhibition of Human Neutrophil Elastase by Pentacyclic Triterpenes. PLoS ONE 8(12).